From the lab
Articles
Here we try to go beyond the abstract, giving our insights into the intuitions, methods, and implications behind our papers, mostly for a non-specialist audience.
Jul 2023
SHAPEIT5 phasing rare variants
Phasing Singletons: Breaking a 20-Year Barrier in Statistical Genetics
For two decades, population-based phasing methods reported 50% switch error at singleton variants — equivalent to random guessing. SHAPEIT5 changes this, and here's how.
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Jul 2023
GLIMPSE2 imputation UK Biobank
How We Imputed from 150,000 UK Biobank Genomes for Under $0.1 per sample
The UK Biobank's WGS release was an extraordinary resource — but existing imputation methods couldn't cope at that scale. Here's how GLIMPSE2 was redesigned from the ground up.
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