Lab logo
CompStatGen Lab
FIMM · Helsinki

Papers & preprints

Selected publications

2026

MetaGLIMPSE: Meta-imputation of low-coverage sequencing data for modern and ancient genomes

Kumar KH, Rubinacci S, Zӧllner S

Am. J. Hum. Genet. 113, 472–482

MetaGLIMPSElcWGSimputationancient genomes doi:10.1016/j.ajhg.2026.02.004 ↗
2026

Insights into DNA repeat expansions among 900,000 biobank participants

Hujoel MLA, Handsaker RE, Tang D, Kamitaki N, Mukamel RE, Rubinacci S, Palamara PF, McCarroll SA, Loh P-R

Nature 650, 920–929

repeat expansionsbiobankNature doi:10.1038/s41586-025-09886-z ↗
2026

Pharmacogenomic architecture of antihypertensive switching implicates neurotensin-NTSR1 signaling in ACE inhibitor-induced cough

Vaura F, Krebs K, Kiiskinen T, Rämö J, Tamlander M, FinnGen, Estonian Biobank research team, Rubinacci S, Milani L, Ripatti S

medRxiv 2026.01.26.26344813

pharmacogenomicsFinnGenEstonian BiobankmedRxiv doi:10.64898/2026.01.26.26344813 ↗
2025

Parent-of-origin effects on complex traits in up to 236,781 individuals

Hofmeister RJ, Cavinato T, Karimi R, van der Graaf A, Pajuste F-D, Kronberg J, Taba N, Estonian Biobank research team, Mägi R, Vaudel M, Rubinacci S, Johansson S, Milani L, Delaneau O, Kutalik Z

Nature 646, 647–656

parent-of-origincomplex traitsEstonian Biobank doi:10.1038/s41586-025-09357-5 ↗
2025

Patterns and drivers of 43,617 mosaic chromosomal alterations in blood

Tang D, Kamitaki N, Mukamel RE, Rubinacci S, Loh P-R

medRxiv 2025.07.30.25332451

mosaic chromosomal alterationsblood traitsmedRxiv doi:10.1101/2025.07.30.25332451 ↗
2025

Noncoding rare variant associations with blood traits in 166,740 UK Biobank genomes

Ribeiro DM, Hofmeister R, Rubinacci S, Delaneau O

Nat. Genet. 57, 2146–2155

UK Biobankrare variantsblood traits doi:10.1038/s41588-025-02288-x ↗
2024

A Genomics England haplotype reference panel and imputation of UK Biobank

Shi S, Rubinacci S, Hu S, Moutsianas L, Stuckey A, Need AC, Palamara PF, Caulfield M, Marchini J, Myers S

Nat. Genet. 56, 1800–1803

Genomics EnglandUK Biobankimputation doi:10.1038/s41588-024-01868-7 ↗
2023

Imputation of low-coverage sequencing data from 150,119 UK Biobank genomes

Rubinacci S, Hofmeister RJ, Sousa da Mota B, Delaneau O

Nature Genetics

GLIMPSE2UK BiobanklcWGS doi:10.1038/s41588-023-01438-3 ↗
2023

Accurate rare variant phasing of whole-genome and whole-exome sequencing data in the UK Biobank

Hofmeister RJ, Ribeiro DM, Rubinacci S, Delaneau O

Nature Genetics

SHAPEIT5UK Biobankrare variants doi:10.1038/s41588-023-01415-w ↗
2023

Imputation of ancient human genomes

Sousa da Mota B, Rubinacci S, Cruz Dávalos DI, G Amorim CE, Sikora M, Johannsen NN, Szmyt MH, Włodarczak P, Szczepanek A, Przybyła MM, Schroeder H, Allentoft ME, Willerslev E, Malaspinas A-S, Delaneau O

Nat. Commun. 14, 3660

ancient DNAimputationNat Commun doi:10.1038/s41467-023-39202-0 ↗
2021

Efficient phasing and imputation of low-coverage sequencing data using large reference panels

Rubinacci S, Ribeiro DM, Hofmeister RJ, Delaneau O

Nature Genetics 53, 120–126

2020

Genotype imputation using the Positional Burrows Wheeler Transform

Rubinacci S, Delaneau O, Marchini J

PLOS Genetics 16(11): e1009049

2020

The molecular basis, genetic control and pleiotropic effects of local gene co-expression

Ribeiro D, Rubinacci S, Ramisch A, Hofmeister R, Dermitzakis E, Delaneau O

Nat. Commun. 12, 4842

gene expressionco-expressionpleiotropy doi:10.1038/s41467-021-25129-x ↗

Full publication list available on ORCID.